The present work describes a validated Stability Indicating RP-HPLC method for estimation of Tenoxicam in bulk and pharmaceutical dosage form. Chromatography was performed on a Varian C18 column (250 mm x 4.6 mm i.d., 5 µm particle size), column with mobile phase containing methanol and acetate buffer in the ratio (40:60, v/v) and pH of acetate buffer adjusted to 4.6 with glacial acid .The flow rate was 1.2 ml/min and the eluent was monitored at 369 nm. The selected chromatographic conditions were found to effectively separate Tenoxicam (RT- 4.170 min). Linearity for Tenoxicam was found in the range of 4-20μg/ml. The value obtained of LOD was 0.146µg/ml and LOQ was 0.444 µg/ml for Tenoxicam. The results of stress testing undertaken according to the International Conference on Harmonization (ICH) guidelines reveal that the method is selective and stability-indicating. The proposed method is simple, accurate, and precise and has ability to separate drug from degradation products and excipients found in the dosage forms.
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